What is a biologic drug (biologics)?
- A biologic drug (biologics) is a product that is produced from living organisms or contain components of living organisms.
- Biologic drugs include a wide variety of products derived from human, animal, or microorganisms by using biotechnology.
- Types of biologic drugs include vaccines, blood, blood components, cells, allergens, genes, tissues, and recombinant proteins.
- Biologic products may contain proteins that control the action of other proteins and cellular processes, genes that control production of vital proteins, modified human hormones, or cells that produce substances that suppress or activate components of the immune system.
- Biologic drugs are sometimes referred to as biologic response modifiers because they change the manner of operation of natural biologic intracellular and cellular actions.
What are biologics used for?
Biologic drugs are used for treatment of numerous diseases and conditions, and are the most advanced therapies available. Some biologic drugs are used for the treatment of Crohn's disease, ulcerative colitis, rheumatoid arthritis, and other autoimmune diseases.
Available biologics have revolutionized cancer treatment, delayed or reversed the course of immune related conditions, changed the lives of people with rare diseases, and have offered hope for many patients who previously had no effective treatment options for their condition.
Examples of medical uses for biologic drugs include:
- Various cancers
- Rheumatoid arthritis (RA)
- Ankylosing spondylitis
- Crohn's disease
- Ulcerative colitis
- Psoriasis
- Diabetes
- Multiple sclerosis (MS)
- Heart attack
- Systemic lupus erythematous
- Age-related macular degeneration
- Diabetic retinopathy
- Prevention of pneumonia
- Anemia
- Chronic migraine
- Hepatitis B
- Hemophilia
- Respiratory syncytial virus (RSV) prophylaxis
- HPV prevention
- Varicella virus vaccine
- Growth hormone deficiency
- Osteoporosis
- Allergic asthma
- Chronic idiopathic urticaria
- Infertility
- Prevention of meningococcal disease
- Cystic fibrosis
- Paroxysmal nocturnal hemoglobinuria
QUESTION
See AnswerWhat are the side effects of biologics?
Side effects of a biologic drug depends on the specific biologic drug, and method of introduction into the body.
- Most biologic drugs have the potential to cause allergic hypersensitivity reactions.
- Biologic drugs that are used for rheumatoid arthritis, psoriasis, and other immune related disorders suppress the immune system and increase the risk of infections.
- Since some biologic drugs are given by injection they also can cause injection site reactions.
- Other biologic drugs are given intravenously and can cause infusion reactions.
These side effects are compiled from side effects listed for several biologic drugs. Each type of biologic drug has its own specific side effect profile and may or may not cause the side effects listed here.
Common side effects of biologic drugs include:
- Allergic reactions
- Injection site reactions
- Chills
- Weakness
- Diarrhea
- Nausea
- Vomiting
- Rash
- Itching
- High blood glucose levels
- Cough
- Constipation
Other side effects of biologic drugs include:
- Shortness of breath
- Peripheral edema
- Headache
- Fever
- Muscle aches and pain
- Decreased appetite
- Increased triglyceride levels
- Insomnia
- Abdominal pain
- Back pain
- Dizziness
- Infusion reactions
Serious side effects of biologic drugs include:
- Low blood pressure
- Anaphylaxis
- Serious infections
- Cancer
- Serum sickness
- Autoimmune thyroiditis
- Arterial and venous blood clots
- Congestive heart failure
- Bleeding
- Interstitial lung disease
- Hepatitis
- Generation of antibodies
- Enterocolitis
- Gastrointestinal perforation
- Mucositis
- Stomatitis
- Anemia
- Reduced white blood cell counts
- Hypothyroidism
What preparations are available for biologics?
Biologic drugs are administered by injection or infusion because they are proteins that are quickly digested and inactivated if given by mouth. Therefore, biologic drugs are supplied as powders for infusion or solutions for injection.
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Which drugs interact with biologics?
- Biologic drugs, for example, adalimubab (Humira), that affect the immune system may interfere with the effectiveness of vaccines. Live vaccines, including attenuated vaccines, should not be used while patients are being treated with biologics that affect the immune system. Patients should complete all recommended immunizations prior to receiving these types of biologic drygs. Prescreening for dormant tuberculosis (TB) generally is recommended.
- Serious infections are more likely to occur when biologic drugs that suppress the immune system are combined with other drugs that also suppress the immune system.
Are biologics safe to use during pregnancy or while breastfeeding?
- Most biologic drugs have not been adequately studied in pregnant women or women who are breastfeeding.
- Some biologics, for example follitropin alpha (Gonal f), nivolumab (Opdivo), and pembrolizumab (Keytruda), may be harmful to the fetus because of their mechanism of action and the results from animal studies.
- Some biologic drugs may be present in breast milk. Mothers who are breastfeeding should decide with their doctors whether or not to stop or discontinue the biologic because many drugs are excreted in breast milk and there may present a risk of serious adverse effects in the infant.
What brand and generic names are available for biologics?
List of examples of brand and generic biologic drugs available in the US
- abatacept (Orencia)
- abciximab (ReoPro)
- abobotulinumtoxinA (Dysport)
- adalimumab (Humira)
- adalimumab-atto (Amjevita)
- ado-trastuzumab emtansine (Kadcyla)
- aflibercept (Eylea)
- agalsidase beta (Fabrazyme)
- albiglutide (Tanzeum)
- aldesleukin (Proleukin)
- alemtuzumab (Campath, Lemtrada)
- alglucosidase alfa (Myozyme, Lumizyme)
- alirocumab (Praluent)
- alteplase, cathflo activase (Activase)
- anakinra (Kineret)
- asfotase alfa (Strensiq)
- asparaginase (Elspar)
- asparaginase erwinia chrysanthemi (Erwinaze)
- atezolizumab (Tecentriq)
- basiliximab (Simulect)
- becaplermin (Regranex)
- belatacept (Nulojix)
- belimumab (Benlysta)
- bevacizumab (Avastin)
- bezlotoxumab (Zinplava)
- blinatumomab (Blincyto)
- brentuximab vedotin (Adcetris)
- canakinumab (Ilaris)
- capromab pendetide (ProstaScint)
- certolizumab pegol (Cimzia)
- cetuximab (Erbitux)
- collagenase (Santyl)
- collagenase clostridium histolyticum (Xiaflex)
- daclizumab (Zenapax)
- daclizumab (Zinbryta)
- daratumumab (Darzalex)
- darbepoetin alfa (Aranesp)
- denileukin diftitox (Ontak)
- denosumab (Prolia, Xgeva)
- dinutuximab (Unituxin)
- dornase alfa (Pulmozyme)
- dulaglutide (Trulicity)
- ecallantide (Kalbitor)
- eculizumab (Soliris)
- elosulfase alfa (Vimizim)
- elotuzumab (Empliciti)
- epoetin alfa (Epogen/Procrit)
- etanercept (Enbrel)
- etanercept-szzs (Erelzi)
- evolocumab (Repatha)
- filgrastim (Neupogen)
- filgrastim-sndz (Zarxio)
- follitropin alpha (Gonal f)
- galsulfase (Naglazyme)
- glucarpidase (Voraxaze)
- golimumab (Simponi)
- golimumab injection (Simponi Aria)
- ibritumomab tiuxetan (Zevalin)
- idarucizumab (Praxbind)
- idursulfase (Elaprase)
- incobotulinumtoxinA (Xeomin)
- infliximab (Remicade)
- infliximab-dyyb (Inflectra)
- interferon alfa-2b (Intron A)
- interferon alfa-n3 (Alferon N Injection)
- interferon beta-1a (Avonex, Rebif)
- interferon beta-1b (Betaseron, Extavia)
- interferon gamma-1b (Actimmune)
- ipilimumab (Yervoy)
- ixekizumab (Taltz)
- laronidase (Aldurazyme)
- mepolizumab (Nucala)
- methoxy polyethylene glycol-epoetin beta (Mircera)
- metreleptin (Myalept)
- natalizumab (Tysabri)
- necitumumab (Portrazza)
- nivolumab (Opdivo)
- obiltoxaximab (Anthim)
- obinutuzumab (Gazyva)
- ocriplasmin (Jetrea)
- ofatumumab (Arzerra)
- olaratumab (Lartruvo)
- omalizumab (Xolair)
- onabotulinumtoxinA (Botox)
- oprelvekin (Neumega)
- palifermin (Kepivance)
- palivizumab (Synagis)
- panitumumab (Vectibix)
- parathyroid hormone (Natpara)
- pegaspargase (Oncaspar)
- pegfilgrastim (Neulasta)
- peginterferon alfa-2a (Pegasys)
- peginterferon alfa-2b (PegIntron, Sylatron)
- peginterferon beta-1a (Plegridy)
- pegloticase (Krystexxa)
- pembrolizumab (Keytruda)
- pertuzumab (Perjeta)
- ramucirumab (Cyramza)
- ranibizumab (Lucentis)
- rasburicase (Elitek)
- raxibacumab
- reslizumab (Cinqair)
- reteplase (Retavase)
- rilonacept (Arcalyst)
- rimabotulinumtoxinB (Myobloc)
- rituximab (Rituxan)
- romiplostim (Nplate)
- sargramostim (Leukine)
- sebelipase alfa (Kanuma)
- secukinumab (Cosentyx)
- siltuximab (Sylvant)
- tbo-filgrastim (Granix)
- tenecteplase (TNKase)
- tocilizumab (Actemra)
- trastuzumab (Herceptin)
- ustekinumab (Stelara)
- vedolizumab (Entyvio)
- ziv-aflibercept (Zaltrap)
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Summary
A biologic drug is a product that is produced from living organisms or contain components of living organisms. Biologics include recombinant proteins, tissues, genes, allergens, cells, blood components, blood, and vaccines. Biologics are used to treat numerous disease and conditions, for example, anemia, chronic migraine, hepatitis B, hemophilia, respiratory syncytial virus (RSV) prophylaxis, HPV prevention, rheumatoid arthritis, inflammatory bowel disease.
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Osteoporosis
Learn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone fracture. Unless one experiences a fracture, a person may have osteoporosis for decades without knowing it. Treatment for osteoporosis may involve medications that stop bone loss and increase bone strength and bone formation, as well as quitting smoking, regular exercise, cutting back on alcohol intake, and eating a calcium- and vitamin D-rich balanced diet.
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Is Respiratory Syncytial Virus (RSV) Contagious?
Respiratory syncytial virus (RSV) is a contagious viral infection that causes symptoms such as decreased appetite, runny nose, sneezing, coughing, and mild fever. The incubation period is 4-6 days, and the contagious period ends after the symptoms disappear.
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14 Early Signs of Arthritis in the Legs
Leg arthritis affects the joints of the hips, knees, ankles or feet. The early signs and symptoms of arthritis in the legs include pain, swelling, stiffness, decreased range of motion, trouble walking, fever, bump-like swelling, and other symptoms.
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Inflammatory Bowel Disease (IBD)
The inflammatory bowel diseases (IBD) are Crohn's disease (CD) and ulcerative colitis (UC). The intestinal complications of Crohn's disease and ulcerative colitis differ because of the characteristically dissimilar behaviors of the intestinal inflammation in these two diseases.
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How Long Can You Live With Juvenile Arthritis?
Juvenile arthritis (JA) has a high mortality rate and life expectancy for people with the condition may be reduced by as much as 10 years.
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16 Early Rheumatoid Arthritis (RA) Signs & Symptoms
Early rheumatoid arthritis (RA) symptoms and signs vary differently from person to person. The most common body parts that are initially affected by RA include the small joints of the hands, wrists, and feet, and the knees and hip joints. Joint inflammation causes stiffness. Warmth, redness, and pain may vary in degree.
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Macular Degeneration
Age-related macular degeneration (AMD) is a disease that gradually destroys the central vision. In people over 60, AMD is a leading cause of vision loss. Wet AMD occurs when abnormal blood vessels behind the retina start to grow under the macula, leaking blood and fluid and causing rapid vision loss. In dry AMD, light-sensitive cells slowly break down in the macula, resulting in gradual vision loss. Pain is not associated with either form of AMD.
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What Is the Best Infusion for Rheumatoid Arthritis (RA)?
Learn the four most effective DMARDs for rheumatoid arthritis infusion therapy, which aim to control RA symptoms, reduce complications, and improve quality of life and lifespan.
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Asthma
Asthma is a condition in which hyperreactive airways constrict and result in symptoms like wheezing, coughing, and shortness of breath. Causes of asthma include genetics, environmental factors, personal history of allergies, and other factors. Asthma is diagnosed by a physician based on a patient's family history and results from lung function tests and other exams. Inhaled corticosteroids (ICS) and long-acting bronchodilators (LABAs) are used in the treatment of asthma. Generally, the prognosis for a patient with asthma is good. Exposure to allergens found on farms may protect against asthma symptoms.
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Early Signs and Symptoms of Arthritis in Knuckles
Pain, swelling, and tenderness are usually considered as early signs and symptoms of knuckle arthritis. Tiny bumps pop out on the top knuckles of some of the fingers, and fingers become stiff.
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How Do You Get Rid of Genital Psoriasis?
Genital psoriasis has no cure, but treatment can help manage symptoms and prevent flare-ups. Here are 6 ways to get rid of genital psoriasis.
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12 Early Signs of Arthritis in Hands
Hand arthritis occurs when there is inflammation in one or more joints of the hand and wrist. A few of the common types of arthritis that affect the hands are osteoarthritis, rheumatoid arthritis, post-traumatic arthritis (arthritis as a result of an injury), psoriatic arthritis and gout.
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Crohn's Disease
Crohn's disease is a chronic inflammatory disease, primarily involving the small and large intestine, but which can affect other parts of the digestive system as well. Abdominal pain, diarrhea, vomiting, fever, and weight loss are common symptoms and signs.
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Hemophilia A and B (Bleeding Disorders)
Hemophilia is defined as one of a group of inherited bleeding disorders. Hemophilia A and hemophilia B are inherited in an X-linked recessive genetic pattern. Symptoms of hemophilia include bleeding into the: joints, muscles, GI or urinary tract, or brain or skull. Hemophilia treatment generally involves the replacement of blood clotting factors.
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Osteoarthritis vs. Osteoporosis Differences and Similarities
Arthritis is defined as painful inflammation and joint stiffness. Osteoarthritis is a type of arthritis and the most common cause of chronic joint pain, affecting over 25 million Americans. Osteoarthritis is a type of arthritis that involves the entire joint. Osteoporosis is not a type of arthritis. It is a disease that mainly is caused by a loss of bone tissue that is not limited to the joint areas. It is possible for one person to have both osteoarthritis and osteoporosis. The differences in the signs and symptoms of osteoarthritis and osteoporosis include; pain, stiffness, and joint swelling, joint deformity, crackle sounds when the joint is moving, and walking with a limp. Osteoporosis is called the "silent disease" because it can progress for years without signs and symptoms before it is diagnosed, severe back pain, bone fractures, height loss, and difficulty or inability to walk. The differences in the causes of osteoarthritis and osteoporosis are that osteoarthritis usually is caused by wear and tear on the joints. Osteoporosis usually is caused by one or more underlying problems, for example, calcium and vitamin D deficiencies. Treatment for osteoarthritis and osteoporosis are not the same. There is no cure for osteoarthritis or osteoporosis.
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Fungal Arthritis
Fungal arthritis is inflammation of a joint by a fungus that has invaded the body and is growing in the normally sterile joint. Fungal arthritis symptoms and signs include pain, redness, loss of range of motion, and swelling. Fungal arthritis treatment includes antibiotics, adequate drainage of the joint, and sometimes surgery.
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Atopic Dermatitis vs Psoriasis
Psoriasis and atopic dermatitis are common, long-term skin diseases. Both are noncontagious. Because both the rashes look somewhat similar, the diagnosis may be difficult at the first glance, and a biopsy of the skin remains the last resort. However, certain things that can help differentiate between the two before the doctor orders a biopsy.
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Does Psoriasis Have a Smell?
There are several types of psoriasis and none of the types have any smell. If you notice an odor from your psoriasis, it is possible that there is a secondary bacterial or fungal infection on the affected skin.
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Is Hepatitis Contagious?
Hepatitis means "inflammation of the liver," and there are several different types of such as A, B, C, D, and E. Some types of hepatitis are contagious and some types are not. Hepatitis symptoms vary upon the type of disease; however, the following symptoms may develop in someone with hepatitis: fatigue, nausea and vomiting, abdominal pain and discomfort, jaundice (yellowing of the skin and whites of the eyes), and loss of appetite. Treatment for hepatitis depends upon the cause. Some types of hepatitis have a vaccine to prevent spread of disease such as hepatitis A and B.
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Rheumatoid Arthritis vs. Polymyalgia Rheumatica
Polymyalgia rheumatica and rheumatoid arthritis are two diseases that manifest in a similar manner.
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Rheumatoid Arthritis vs. Lupus: Differences and Similarities
Rheumatoid arthritis (RA) and lupus are two varieties of autoimmune diseases that cause flare-ups. While RA attacks the immune system on the joints, lupus involves many other parts of the body besides the joints. Common RA symptoms involve warm, swollen, and painful joints; morning stiffness in the joints or stiffness after inactivity, joint deformity, fever, fatigue, etc. Lupus symptoms include Malar rash (butterfly-shaped rash involving the cheeks and bridge of the nose), fever, joint pain in the absence of joint deformity, etc.
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Asthma Medications
There are two types of asthma medications: long-term control with anti-inflammatory drugs and quick relief from bronchodilators. Asthma medicines may be inhaled using a metered-dose inhaler or nebulizer or they may be taken orally. People with high blood pressure, diabetes, thyroid disease, or heart disease shouldn't take OTC asthma drugs like Primatene Mist and Bronkaid.
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Is Colitis Contagious?
Colitis is a term that us used to describe inflammation of the colon. The terms enteritis, proctitis, and inflammatory bowel disease (IBD) now include colitis. Colitis has many different causes. Some types of colitis are contagious and some are not contagious. Symptoms and signs of colitis include diarrhea, abdominal discomfort, cramping, pain, and blood in the stools. Treatment for colitis depends on the cause and type of colitis.
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Should You Brush Scalp Psoriasis?
It is beneficial to brush your scalp with scalp brushes because it massages and exfoliates the scalp. To remove psoriasis scales, it is advisable to brush your hair and scalp with care.
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Is Hepatitis B Contagious?
Hepatitis B is a type of liver infection. Hepatitis B is spread through person-to-person contact or through personal items like razors, toothbrushes, etc. Symptoms of hepatitis B include fever, yellowish skin (jaundice), dark urine, fatigue, nausea, and vomiting. There is no drug to cure hepatitis B; however, there is a hepatitis B vaccine available.
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11 Home Remedies for Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a long-term disorder that progressively affects many parts of the body. Home remedies, diet, and lifestyle changes can help reduce pain and discomfort associated with RA alongside medical treatment. Home remedies alone cannot effectively treat RA or prevent the progression of the disease.
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Arthritis in Knee: 4 Stages of Osteoarthritis
Painful joint swelling is called arthritis. Osteoarthritis is due to wear and tear of the joints over many years. Arthritis maye develop in any joint, including the fingers, hips and knees. Usually, patients with arthritis feel pain in their joints even after moderate movements. There are four stages of osteoarthritis of the knee.
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17 Early Signs of Arthritis in the Back
Arthritis in the back arises due to the inflammation of facet joints in the spine or sacroiliac joints between the spine and the pelvis. Some of the early signs of arthritis in the back include back pain, stiffness, swelling, bone grinding, loss of flexibility, fatigue, muscle spasms and other symptoms.
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Hepatitis B (HBV, Hep B)
The hepatitis B virus (HBV, hep B) is a unique, coated DNA virus belonging to the Hepadnaviridae family of viruses. The course of the virus is determined primarily by the age at which the infection is acquired and the interaction between the virus and the body's immune system. Successful treatment is associated with a reduction in liver injury and fibrosis (scarring), a decreased likelihood of developing cirrhosis and its complications, including liver cancer, and a prolonged survival.
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What Deficiency Causes Scalp Psoriasis?
Scientific studies have reported a possible link between vitamin D deficiency and psoriasis, including scalp psoriasis.
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Are Hives (Urticaria) Contagious?
Hives are not contagious are triggered by an allergic response to a substance. Symptoms and signs of hives include a raised, itchy red rash on the skin. An individual should seek medical care for hives if he or she develops dysphagia, wheezing, shortness of breath, or throat tightening.
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Genital Warts in Men (HPV)
The HPV virus (genital warts) in men can cause health problems. Genital warts are confined primarily to the moist skin of the genitals or around the anus. Genital warts are caused by the human papillomaviruses (HPVs), which are transmitted through sexual contact.
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How to Get Rid of Psoriasis Quickly
Although psoriasis is incurable, it responds to topical and systemic treatments. Topical treatments that may be effective to treat mild psoriasis include creams, lotions, and sprays.
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Scalp Psoriasis (Psoriasis of the Scalp)
Scalp psoriasis causes red, raised, scaly patches that may extend from the scalp to the forehead and the back of the neck and ears. Symptoms and signs include itching, hair loss, flaking, silvery scales, and red plaques. Treatment includes topical medicated shampoos, creams, gels, oils, ointments, and soaps, medications, and light therapy.
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What Foods Trigger Arthritis Attacks?
Exercising regularly and eating a healthy diet can help you manage arthritis. Learn which foods to avoid and which foods to eat with arthritis.
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Can Rheumatoid Arthritis Be Caused by Stress?
Rheumatoid arthritis can be caused by and result in stress, as well as other conditions such as gastrointestinal problems (IBD).
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Can Rheumatoid Arthritis Affect Your Ability to Walk? 9 Limitations
Rheumatoid arthritis can impair your walking ability and result in the following nine types of functional limitations.
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Do Steroids Help With Arthritis?
Arthritis is the inflammation of one or more joints in the body. The disease is one of the most common chronic health conditions in the United States. Steroids are a class of drugs that reduce inflammation and have a suppressing effect on the immune system.
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Rheumatoid Arthritis vs. Fibromyalgia
Though rheumatoid arthritis (RA) and fibromyalgia have similar symptoms, RA is an autoimmune disease and fibromyalgia is a chronic pain syndrome. RA symptoms include joint redness, swelling, and pain that lasts more than 6 weeks. Fibromyalgia symptoms include widespread pain, tingling feet or hands, depression, and bowel irritability. Home remedies for both include stress reduction, exercise, and getting enough sleep.
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Does Hand Grip Help With Arthritis?
Because your hands are engaged in multiple functions every day, hand strength is a powerful predictor of your overall capacity to function and how severe your arthritis is.
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Rheumatoid Arthritis vs. Arthritis
Arthritis is a general term used to describe joint disease. Rheumatoid arthritis (RA) is a type of arthritis in which the body’s immune system mistakenly attacks the joints, causing chronic inflammation.
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Rheumatoid Arthritis vs. Ankylosing Spondylitis
Learn the differences between rheumatoid arthritis and ankylosing spondylitis below.
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What Is Asthma? 19 Complex Facts
There are many unusual symptoms of asthma, including sighing, difficulty sleeping, anxiety, chronic cough, recurrent walking pneumonia, and rapid breathing. These symptoms may vary from individual to individual. These asthma complexities make it difficult to accurately diagnose and treat asthma.
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Juvenile Rheumatoid Arthritis (JRA)
Juvenile rheumatoid arthritis (JRA) annually affects one child in every thousand. There are six types of JRA. Treatment of juvenile arthritis depends upon the type the child has and should focus on treating the symptoms that manifest.
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Is Crohn's Disease Contagious?
Crohn's disease, a form of inflammatory bowel disease (IBD), and is characterized by symptoms and signs that include diarrhea, fever, weight loss, vomiting, and abdominal pain. Though Crohn's disease is not contagious it can spread throughout a person's gastrointestinal tract. An increase in the above symptoms and signs warrants a visit to a doctor's office.
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What Does Psoriatic Arthritis Joint Pain Feel Like?
Psoriatic arthritis may lead to various degrees of inflammation, swelling, stiffness, and pain in the joints, especially on one side of the body. Pain caused in the joints can be debilitating and reduce mobility.
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What Is the Main Cause of Psoriasis?
Psoriasis is a non-contagious skin disease in which the skin cells grow in numbers faster than normal, producing rashes on the body. Normally, the cells on the surface of the skin are shed as new cells grow beneath. In psoriasis, the swift build-up of skin cells collects on the surface of the skin as scales or plaques. The exact cause of psoriasis is not completely understood. It appears to involve an interplay between a person’s genes, immune system and environment.
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How Serious Is Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is a chronic inflammatory disorder that typically affects the joints and other body parts. If not diagnosed early and appropriately treated, RA can lead to permanent deformities, disabilities, and serious systemic complications.
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What Makes Guttate Psoriasis Worse?
Guttate psoriasis is often made worse by a bacterial infection, typically Streptococcus (strep throat). Learn about common triggers of guttate psoriasis.
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Paroxysmal Nocturnal Hemoglobinuria (PNH)
Paroxysmal nocturnal hemoglobinuria or PNH is a rare genetic disease in which there is an abnormal breakdown of red blood cells. Symptoms of PHN include irregular heartbeats, chest pain, abdominal pain, anemia, jaundice, seizures, and blood clots in the legs (DVTs). Treatment for PNH is directed toward the symptoms of the disease.
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Early Signs of Arthritis in the Fingers
The earliest signs of arthritis are pain, swelling and stiffness. If these symptoms are experienced in the fingers, it is likely because of rheumatoid arthritis. The signs and symptoms of arthritis in the fingers include popping sounds, joint deformity, warmth, mucus cysts and bone spurs.
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Early Signs of Arthritis in the Feet
There are more than 30 joints in the ankle and feet. Arthritis can affect one or multiple joints in the feet. Excess weight, hereditary tendencies, old injuries, and poor footwear are a few predisposing factors of arthritis.
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Is Lupus Contagious?
Systemic lupus erythematosus in an inflammatory disease. Symptoms and signs include joint pain, fever, and rash. Though lupus is incurable, early medical intervention can help to reduce inflammation and protect the affected individual's organs.
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What Triggers Genital Psoriasis?
Triggers of genital psoriasis may include stress, smoking, excessive alcohol consumption, injury to the skin, medications, infections, and obesity.
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Is Crohn's Disease Related to Rheumatoid Arthritis?
Since Crohn’s disease causes inflammation of the body, including the joints, sufferers are at a greater risk of developing rheumatoid arthritis.
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How Do You Manage Inverse Psoriasis?
Although there is no permanent cure for inverse psoriasis, treatment can help manage and alleviate symptoms, including itching and discoloration.
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Is Psoriasis Contagious?
Psoriasis is an incurable skin disease that causes reddish patches of skin topped with a thick layer of dry silvery scales. Psoriasis cannot spread and is not contagious.
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Safest Rheumatoid Arthritis Drugs During Pregnancy
None of the drugs used in the treatment of rheumatoid arthritis (RA) is completely safe during pregnancy. You must discuss with your physician regarding the decision to use, modify, or stop any medications.
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What Is the Difference Between Arthritis and Osteoarthritis?
Arthritis is a broad term that refers to the inflammation of the joints. There are over 100 types of arthritis, and osteoarthritis is the most common type.
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How Do You Stop Guttate Psoriasis From Spreading?
While there is no definitive way to stop guttate psoriasis from spreading, you can take steps to lower the risk of a flare-up and prevent symptoms from worsening.
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Can You Treat Eczema and Psoriasis the Same Way?
Both eczema and psoriasis are hereditary and ongoing skin conditions that cause irritated and inflamed skin. Treatment for eczema and psoriasis depends on the type and the severity.
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Osteoarthritis vs. Rheumatoid Arthritis
Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic joint disorders. RA is also an autoimmune disease. OA and RA symptoms and signs include joint pain, warmth, and tenderness. Over-the-counter pain relievers treat both diseases. There are several prescription medications that treat RA.
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Breastfeeding With Rheumatoid Arthritis
You can breastfeed your baby even if you have rheumatoid arthritis (RA). However, you must always consult your doctor before you start the process.
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How Do You Stop Arthritis From Progressing in Your Hands?
Learn these simple tips and tricks to help stop the progression of arthritis in your hands.
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What Is the Difference Between Eczema and Psoriasis?
Allergies and skin reactions trigger eczema. Psoriasis isn't triggered by allergies. Signs and symptoms of eczema include skin redness, swelling, and itching while psoriasis symptoms and signs include thick, red, itchy, and scaly patches of skin.
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Is Rheumatoid Arthritis Caused by Sugar?
Despite insufficient evidence, studies have found that people with rheumatoid arthritis may experience worsening symptoms with sugary foods.
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What Is the Best Treatment for Psoriasis?
Psoriasis is an incurable chronic autoimmune disorder of the skin that causes patches of thick, flaky, scaly skin, mostly around the scalp, knees, and elbows, though any skin surface may be involved. Some people experience only small patches while others have red, inflamed skin and think scaly patches all over the body. The exact cause of psoriasis is not clear, but it isn’t contagious.
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Rheumatoid Arthritis vs. Osteoarthritis Hands
Two of the most frequent types of arthritis are osteoarthritis and rheumatoid arthritis.
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What Is Mild to Moderate Psoriasis?
Mild to moderate psoriasis is when the psoriatic scales or plaques (raised surfaces with a silvery cover of dead skin cells) cover less than five percent of the body surface area.
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How Can You Live With Arthritis in Your Back?
Arthritis in the back can be extremely painful and in some cases debilitating. However, effective ways to manage and live with the condition.
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What Are the Levels of Psoriasis? 5 Types
Learn the three levels of psoriasis, as well as the five different types, which each include their own symptoms, causes, triggers, treatment, duration, and prevention.
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Early Signs of Arthritis in the Knee
Arthritis refers to the redness and swelling of the joints. It usually develops slowly over 10 to 15 years, interfering with daily life activities. Knowing the early signs of arthritis can help you take appropriate treatment and incorporate modifications in your diet and lifestyle.
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How Do You Stop Psoriasis From Stress?
Psoriasis is an autoimmune skin disease that can be passed down (hereditary) to you from your parents or grandparents. Stress is a common factor that can trigger your psoriasis. Psoriasis has a stronger association with psychiatric disorders than other skin diseases. Stress worsens psoriasis by triggering a complex network of signals between the endocrine (hormones), nervous and immune systems.
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Does Rheumatoid Arthritis Run in Families?
Rheumatoid arthritis (RA) is an autoimmune disease that tends to run in families. Your likelihood of getting RA, however, is not determined by family history of the disease alone. It is also influenced by environmental factors such as age, obesity and smoking.
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What Are the Different Types and Causes of Scalp Psoriasis?
While there is only one type of scalp psoriasis, numerous types of psoriatic conditions can affect the scalp.
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Early Signs of Arthritis in Shoulder
Early signs and symptoms of arthritis in the shoulder include pain in the shoulder joint that's worse when lifting heavy objects, pain that radiates down the arm and shoulder joint sounds like grinding, clicking, and crackling.
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Is Psoriasis Associated With HIV?
Psoriasis is a chronic autoimmune condition that affects the skin. HIV is linked to a higher likelihood of developing psoriasis and more severe symptoms.
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What Triggers Facial Psoriasis?
Possible triggers of facial psoriasis include smoking, obesity, medications, infections, skin injury, stress, vitamin D deficiency, and stress.
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What Causes Nail Psoriasis?
Nail psoriasis is caused by the same autoimmune mechanisms as other types of psoriasis. The immune system attacks normal tissues in the body and triggers rapid cell growth.
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How Do I Know if My Knee Pain Is Arthritis?
If you have knee pain from arthritis you might notice symptoms including stiffness and swelling, increased pain and swelling in the morning or after sitting, increased pain after activity, 'locking' or 'sticking' of the knee, and weakness or buckling in the knee.
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Can Rheumatoid Arthritis Cause Heart Failure?
Rheumatoid arthritis can increase the risk of various cardiovascular diseases including heart failure and pericarditis. Heart failure is one of the common causes of increased mortality in people with RA.
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Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
Non-radiographic spondyloarthritis (nr-axSpA) is an inflammatory arthritis that mainly affects the joints of the spine. Morning stiffness and back pain are the usual symptoms of nr-axSpA. Nonsteroidal anti-inflammatory drugs, exercise, and biologics are treatments for nr-axSpA.
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How Do I Know If It's Carpal Tunnel or Arthritis?
Carpal tunnel syndrome and arthritis have different etiologies; thus, they manifest differently in the hand. Your doctor may subject you to physical examination, radiological tests, and neurological evaluation to diagnose.
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Does JIA Arthritis Go Away?
Juvenile idiopathic arthritis (JIA) is either a short-term or chronic condition. There is no cure for JIA and treatment aims to improve symptoms and achieve remission.
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Can Rheumatoid Arthritis Cause Carpal Tunnel?
Carpal tunnel syndrome is one of the common complications of rheumatoid arthritis. Learn the symptoms, causes, diagnosis, and treatment of carpal tunnel syndrome.
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How Is Psoriatic Arthritis Diagnosed?
Psoriatic arthritis is a painful joint condition associated with psoriasis that is diagnosed through imaging and blood tests when accompanying symptoms are present.
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How Is Inverse Psoriasis Diagnosed?
Diagnosis of inverse psoriasis is typically based on medical history and a clinical examination that assesses the location and appearance of the rash.
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Can Osteoarthritis Be Cured?
Osteoarthritis cannot be cured or reversed; however, effective treatment can reduce its progression and slow down complications.
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Is Genital Psoriasis Life-Threatening?
Although genital psoriasis is neither life-threatening nor contagious, it can be uncomfortable and more difficult to treat than other types of psoriasis.
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Is Pustular Psoriasis an Autoimmune Disease?
Pustular psoriasis is an autoimmune disease that is characterized by yellowish pustules over the skin on an erythematous base.
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Early Signs of Arthritis in the Wrist
Wrist arthritis is inflammation (swelling) of one or more joints of the wrist. Wrist arthritis is long-lasting or permanent and eventually causes severe joint damage. The early signs of arthritis in the wrist include morning stiffness, redness, tenderness, pain, swelling, weakness, warmth and other symptoms.
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Rheumatoid Arthritis vs. Gout
Although gout is often mistaken for rheumatoid arthritis, learn the differences associated with the causes, symptoms, and treatments below.
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Rheumatoid Arthritis vs. Psoriatic Arthritis
Here are the differences between rheumatoid arthritis and psoriatic arthritis.
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Early Signs and Symptoms of Arthritis in Thumb
The earliest sign and symptom of thumb arthritis is pain, swelling, and tenderness with activities that involve pinching action. The pain may be dull, achy, or sharp at the base of the thumb. The pain can occur when we grip, grasp, or pinch an object or use the thumb to apply force.
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How Can I Improve My Grip Strength With Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by gradual joint inflammation and degeneration. Here are five exercises that reduce muscle stiffness and improve pain due to RA.
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Where Does Psoriasis Usually Start?
The most common sites of psoriasis are the scalp, elbows, and knees, although psoriasis can involve any part of the body such as the face, palms, soles, and back.
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How Do You Treat Mild to Moderate Psoriasis?
Mild to moderate psoriasis is typically treated with medications and therapies that aim to reduce inflammation and slow the rapid skin cell growth associated with the condition.
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Is Erythrodermic Psoriasis Rare?
Erythrodermic psoriasis is a very rare and potentially fatal form of psoriasis that affects about 1%-2.2% percent of people with the condition.
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What Is Generalized Pustular Psoriasis?
Generalized pustular psoriasis (GPP) is a rare, severe type of psoriasis that covers large areas of the body and characterized by pus-filled blisters rather than plaques.
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What Is Chronic Plaque Psoriasis?
Chronic plaque psoriasis is a chronic inflammatory skin condition characterized by well-distinguished, erythematous (red and inflamed), scaly plaques on the skin of extensor surfaces.
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Rheumatoid Arthritis vs. Juvenile Arthritis
Rheumatoid arthritis and juvenile arthritis are both types of inflammatory arthritis; however, learn their differences below.
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Is Psoriasis Linked to Anxiety?
Like other chronic conditions, psoriasis can take a toll on your emotional health. Anxiety can trigger or worsen psoriasis, and psoriasis can cause anxiety.
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Does Psoriasis Cause Cardiovascular Disease?
Long-lasting inflammation due to psoriasis can affect your heart and blood vessels, increasing your risk of developing cardiovascular disease, heart attack, or stroke.
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Does Rheumatoid Arthritis Increase Cardiovascular Risk?
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease, which usually affects joints, and can increase the risk of cardiovascular diseases.
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Osteoarthritis and Treatment
Painful swelling of the joints due to wear and tear over many years is called osteoarthritis. Osteoarthritis may develop in any joint that includes the fingers, hips, and knees. There are many treatment options available to curb the complications of arthritis.
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What Are 5 Common Risk Factors to Rheumatoid Arthritis?
Rheumatoid arthritis (RA) is an autoimmune disorder (the body's immune system mistakenly attacks its own cells). Certain factors increase the risk of RA.
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Do Anti-Inflammatories Help Rheumatoid Arthritis?
Rheumatoid arthritis is a chronic inflammatory disorder. Anti-inflammatory medications can help address symptoms of rheumatoid arthritis.
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What Is Intertriginous Psoriasis?
Intertriginous psoriasis, also known as inverse psoriasis, is a rare type of psoriasis that occurs in skin folds, such as the armpits, under the breasts, and groin.
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Are Psoriasis and Psoriatic Arthritis the Same?
Psoriatic arthritis is a type of inflammatory arthritis that occurs due to joint inflammation in people with psoriasis; however, not every person with psoriasis gets psoriatic arthritis.
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What Is the Most Severe Form of Psoriasis?
Erythrodermic psoriasis (EP) or erythroderma is a severe type of psoriasis that causes extensive peeling, severe itching, and rashes across the entire surface of the body.
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What Can Trigger Psoriatic Arthritis?
Triggers of psoriatic arthritis differ from person to person. Learn the nine most common triggers that cause flare-ups of inflammation in some people.
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Can Psoriasis Lead to Psoriatic Arthritis?
It is well established that both psoriatic arthritis and psoriasis are linked. Nearly 30 percent of people with psoriasis develop psoriatic arthritis.
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How Does Psoriasis Affect the Cardiovascular System?
Psoriasis causes inflammation inside your body, which can damage your cardiovascular system over time and increase your risk of heart problems.
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What Is Considered Moderate Plaque Psoriasis?
Moderate plaque psoriasis is when patches cover 3%-10% of your body surface area. Learn about symptoms, causes, triggers, and treatment.
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Is Psoriasis a COVID-19 Risk?
Psoriasis is a chronic, autoimmune, inflammatory condition that primarily affects the skin. There is no definitive link between psoriasis and an increased risk of COVID-19.
Treatment & Diagnosis
- Vaccination Schedule for Adults and Adolescents
- Pneumococcal Vaccination (Pneumonia Vaccine)
- Can Psoriasis Go Away?
- What Are the Four Stages of Osteoarthritis?
- What Is the Best Treatment for Arthritis?
- What Is the Best Treatment for Osteoarthritis?
- What Is the Treatment for Septic Arthritis?
- Physical and Occupational Therapy for Arthritis
- Osteoporosis FAQs
- Rheumatoid Arthritis FAQs
- Psoriasis FAQs
- Asthma FAQs
- Infertility FAQs
- Systemic Lupus Erythematosus FAQs
- Ulcerative Colitis FAQs
- Ankylosing Spondylitis FAQs
- Crohn's Disease FAQs
- Type 2 Diabetes FAQs
- Type 1 Diabetes FAQs
- Will Rheumatoid Arthritis Nodules Go Away?
- What if I get COVID-19 with Rheumatoid Arthritis?
- Are Corticosteroids Safe for Pregnant and Nursing Women with Rheumatoid Arthritis?
- Arthritis Medications
- Psoriasis, Lupus, Rheumatoid Arthritis Share One Gene
- Psoriasis Drugs Strike Immune Targets (Raptiva, Enbrel)
- What Not to Eat When You Have Arthritis
- Can You Get Gout in Your Back?
- What Are the Side Effects of Glucosamine?
- Can Glucosamine Treat Arthritis?
- Does Glucosamine Cream Work for Arthritis?
- Can You Get a Cartilage Transplant?
- How Do You Get Psoriasis?
- Can Psoriasis Be Caused by Allergy?
- Is It Eczema or Psoriasis?
- What Are the Triggers of Psoriasis?
- Can My Diet Improve Arthritis?
- Psoriasis PUVA Therapy Can Increase Melanoma Risk
Medications & Supplements
- trastuzumab - injection, Herceptin
- onabotulinumtoxinA, Botox, Botox Cosmetic
- alteplase (TPA, Activase, Cathflo Activase)
- rituximab (Rituxan)
- Interferon: Potential COVID-19 Treatment
- infliximab (Remicade)
- Trulicity (dulaglutide)
- tocilizumab (Actemra)
- anakinra (Kineret)
- darbepoetin alfa - injection, Aranesp
- abatacept (Orencia)
- epoetin alfa, Epogen, Procrit
- adalimumab (Humira)
- omalizumab (Xolair)
- Herceptin (trastuzumab)
- bevacizumab - injection, Avastin
- belimumab (Benlysta)
- collagenase ointment - topical, Santyl
- pegfilgrastim - injection, Neulasta
- etanercept (Enbrel)
- filgrastim (Neupogen)
- ustekinumab (Stelara)
- certolizumab (Cimzia)
- infliximab-dyyb (Inflectra)
- palivizumab - injection, Synagis
- becaplermin, Regranex
- asparaginase - injection, Elspar
- natalizumab - injection, Tysabri
- Simponi, Simponi Aria (golimumab)
- aldesleukin (Proleukin)
- alemtuzumab (Campath)
- abciximab - injection, Reopro
- collagenase clostridium histolyticum, Xiaflex
- rasburicase - injection, Elitek
- dornase alpha (Pulmozyme)
- interferon beta-1a (Rebif)
- basiliximab - injection, Simulect
- ibritumomab tiuxetan - injection, Zevalin
- sargramostim (Leukine)
- pegaspargase - injection, Oncaspar
- oprelvekin - injection, Neumega
- peginterferon beta-1a (Plegridy)
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
<http://www.fda.gov/AboutFDA/Transparency/Basics/ucm194516.htm>
FDA. "Complete List of Licensed Products and Establishments." Updated: Oct 31, 2016.
<http://www.fda.gov/BiologicsBloodVaccines/ucm133672.htm>